Lablog4-17:ACE inhibitory activity and characteristics of tri-peptides obtained from bonito protein

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Fida Md Hasan, Yuka Kobayashi, Yoichi Kumada, Tomohisa Katsuda, Masaaki Terashima, Shigeo Katoh

First author

Fida Md Hasan

Corresponding author

Shigeo Katoh

Publication Style

Journal name Journal of Chemical Engineering of Japan


Volume, issue, pages

40(1) 59-62


 Inhibition characteristics of tri-peptides IKW and IKY, which were obtained as angiotensin-I converting enzyme inhibitors from bonito protein, and their stability in digestive canal were studied. These IKW and IKY showed high inhibitory activities with IC50 of 0.4 and 1.0 μM, respectively, and acted as competitive inhibitors. The tri-peptides, especially IKY, were very stable under simulated gastrointestinal digestion conditions.